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Module 11, Advanced Toxicology
A deeper dive into the world of toxicology or how chemicals impact humans and why
This module is an advanced training day in toxicology that follows on from Module 5. At the basic level, we learnt that standard test data can provide us with classification end points. At the advanced level we will also learn the basics of human risk assessment such as how to derive a DNEL/DMEL. An advanced level of understanding in toxicology is required when it comes to understand the toxicological mechanisms leading to different toxicological end points. We also learn about the latest achievements in toxicological testing (in chemico, in vitro and in silico methods).
SDS writers reading data most often deal with data from animal studies, but on occasion data from humans that have been exposed (case studies). What kind of challenges are brought forward in handling data from humans and how is data from animals ‘translated’ into what is true for humans?
This module is aimed at those with a reasonable technical understanding of toxicology, chemistry and chemical supply classification.
To ensure the most effective training with optimum involvement in participative exercises, there will be a limit of 14 on the number of students. Attendance on this series of modules will ensure that your SDSs meet the increasing expectations of both your customers and the regulators.
What You Will Learn
This module follows on from Module 5 – Basic Toxicology and builds on basic principles by considering chronic toxicity studies and end points (CMR) in more depth. It will also help those reading data to interpret whenever there is a toxicological concern regarding findings in the literature.
There will be opportunities for delegates to discuss personal experiences and ask questions relating to their own specific range of products.
- Hazard versus risk
- Basic derivation of DNEL (derived no-effect level) including allometric scaling
- The challenge of handling numerous data, including data from human exposure
- Adverse outcome pathway (AOP)
- Basic introduction to Q(SAR), computer models
- Where to find the data – about sourcing of data from the literature
Participants need to bring an electronic copy of the Regulation (EC) No 1272/2008 on Classification, Labelling and Packaging of Substances and Mixtures, including Annexes on a laptop or tablet for use during the exercises.
The latest consolidated version of the CLP Regulation can be downloaded from:
This module will be presented by toxicologist Annette Dock. Annette has over twenty-five years’ experience in chemical regulation and assisting companies with compliance. Annette has worked for central authorities in Sweden (National Food Agency, Swedish Work Environment Authority and Swedish Chemicals Agency) before setting up her own business working as an independent consultant.
“Fantastic development of information presented in Basic Toxicology. Interesting and knowledgeable presenters with great background. Supplementary information with exercise incredibly useful.”
“Good pace and structure of training. Very helpful to my company’s needs.”
“Complex topics were well explained and make sense”
“Particularly enjoyed the discussions on classifications, the group exercise & meeting experts practicing in field”
CHCS is delighted to have an arrangement with the US-based Society for Chemical Hazard Communication (SCHC) whereby SCHC members can attend CHCS events at CHCS member-only rates and vice versa. If you are a member of SCHC and wish to attend this course, please email the CHCS Office at firstname.lastname@example.org providing your name and organisation. We will verify your membership of SCHC then email you back, providing you with details of how to register.
Your Attention Is Drawn To These Conditions
Delegates can be substituted at any time, subject to payment of membership fee if applicable. However, once booked, the full fee is payable. As this is a limited space training event refunds can only be made if CHCS is notified in advance, and is able to successfully re-offer the place to another delegate.
CHCS reserves the right to alter or cancel the programme due to circumstances beyond our control. If CHCS cancels, then refunds will be made.
We only accept credit card payments for registrations made within 5 weeks of the course date.