This module is an advanced training day in toxicology. At the basic level, we learnt that standard test data can provide us with classification end points. At the advanced level we will also learn the basics of human risk assessment such as how to derive a DNEL/DMEL. An advanced level of understanding in toxicology is required when it comes to understand the toxicological mechanisms leading to different toxicological end points.
Who should attend?
This module is aimed at those with a reasonable technical understanding of toxicology, chemistry and chemical supply classification.
The training will be based around the Classification, Labelling and Packaging (CLP) Regulation (EC 1272/2008).
Benefits of attending
Attendance on this series of modules will ensure that your SDSs meet the increasing expectations of both your customers and the regulators. To ensure the most effective training with optimum involvement in participative exercises, there will be a limit of 14 on the number of students.
IOSH members are entitled to include this module in their continuing professional development records.
Comments from previous delegates on this training module
“Very professional & enthusiastic presenter. Questions encouraged & answered fully.”
“A.M. session very good. Complemented my current knowledge. P.M. session extremely useful.”
“Very friendly and informal.”
What you will learn
This module follows on from Module 5 – Basic Toxicology and builds on basic principles by considering chronic toxicity studies and end points (CMR) in more depth. It will also help those reading data to interpret whenever there is a toxicological concern regarding findings in the literature.
- Reminder of definitions/basic terms
- Target organ toxicity (STOT in CLP)
- Mechanisms behind some toxicological end-points (allergy)
- Some of the toxicological end-points in more detail; carcinogenicity, mutagenicity, reproduction toxicity (CMR)
- Basic introduction to Q(SAR), computer models
- Toxicokinetics (absorption, metabolism, excretion)
- Interpretation of data and identification of data that gives rise to toxicological concern (for example regarding classification with STOT)
- Where to find the data – about sourcing of data from the literature
- There will be opportunities for delegates to discuss personal experiences and ask questions relating to their own specific range of products
Legislation
Participants need to bring an electronic copy of the Regulation (EC) No 1272/2008 on Classification, Labelling and Packaging of Substances and Mixtures, including Annexes on a laptop or tablet for use during the exercises.
The latest consolidated version of the CLP Regulation can be downloaded from:
http://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:02008R1272-20131201&rid=1.
Module Tutor
The training will be given by toxicologist Annette Dock. Annette lives in Sweden and after many years experience from working for central authorities in Sweden, now has had her own business running for more than 20 years. Annette has a lot of experience in lecturing to students, as well as in toxicological assessment of substances. She also has a long experience in the preparation of Safety Data Sheets.
Your attention is drawn to the conditions below:
Delegates can be substituted at any time, subject to payment of membership fee if applicable. However, once booked, the full fee is payable. As this is a limited space training event refunds can only be made if CHCS is notified in advance, and is able to successfully re-offer the place to another delegate.
CHCS reserves the right to alter or cancel the programme due to circumstances beyond our control. If CHCS cancels, then refunds will be made.
